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Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study
Author(s) -
Olsen Anne L,
Reinholdt Jes,
Jensen Anders Mørup,
Andersen Leif P,
Jensen Elsebeth Tvenstrup
Publication year - 2009
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2009.01322.x
Subject(s) - medicine , incidence (geometry) , neonatal intensive care unit , prospective cohort study , intensive care unit , intensive care , danish , gestational age , pediatrics , risk factor , intensive care medicine , emergency medicine , pregnancy , linguistics , philosophy , physics , biology , optics , genetics
Aim: The aim of this study was to estimate the incidence and identify independent risk factors for nosocomial infections in a Danish Neonatal Intensive Care Unit and to compare these findings with international results. Methods: The study was performed prospectively from January 1, 2005 to December 31, 2005 in the Neonatal Intensive Care Unit at Rigshospitalet, Copenhagen. Specific criteria for blood stream infection and respiratory tract infection adapted for neonates in our ward were worked out. Results: Six hundred and eighty‐three patients were included. The overall incidence of nosocomial infection was 8.8/1000 hospital days. Blood stream infection was the most frequent type of infection, with an incidence of 5.1/1000 hospital days. Multivariate analysis showed gestational age and heart disease to be significant independent risk factors for both first time blood stream infection and respiratory tract infection, and central venous catheter and parenteral nutrition risk factors for first time blood stream infection. Conclusion: This first prospective study of nosocomial infection in a Danish Neonatal Intensive Care Unit found an overall incidence of 8.8/1000 hospital days, which is low or similar compared to other studies. Further Danish multicentre studies are needed, and we suggest that procedures related to central venous catheters should be a future focus area.