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Breast‐feeding and a subsequent diagnosis of measles
Author(s) -
Silfverdal SA,
Ehlin A,
Montgomery SM
Publication year - 2009
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2008.01180.x
Subject(s) - measles , medicine , breast feeding , breastfeeding , vaccination , measles vaccine , odds ratio , immunization , pediatrics , logistic regression , breast cancer , measles virus , confidence interval , immunology , obstetrics , cancer , antibody
Background: Breast‐feeding protects against many infectious diseases and may also influence immunization outcomes. Aim: This study investigated if breast‐feeding protects against clinical measles and if it modified the effect of immunization. Methods: We used logistic regression with data for 10 207 individuals from the 1970 British Cohort study (BCS70). Breast‐feeding data were collected at five years of age, and information on clinical measles infection, as well as socio‐economic measures was collected at the age of ten years. Breast feeding was categorized as: breast‐fed <1 month (n = 1611), breast‐fed for 1–3 months (n = 1016), breast‐fed for more than three months (n = 1108), breast‐feeding of uncertain duration (n = 21) and never breast‐fed (n = 6451). Results: Breast‐feeding for more than three months was negatively associated with a diagnosis of clinical measles infection after adjustment for crowding, social class, measles vaccination, parity and sex with an odds ratio (95% confidence interval) of 0.69 (0.60–0.81) compared with those who never breast‐fed. Measles vaccination was highly associated with low risk for measles with: 0.14 (0.13–0.16). Age at acute measles infection was not associated with breastfeeding. Breast‐feeding did not notably alter measles immunization efficacy. Conclusion: Immunization against measles provides effective protection against the disease. A more modest reduction in the risk of a measles diagnosis is associated with breast‐feeding. The associations with a diagnosis of measles for breast‐feeding and measles immunization are independent of each other.