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Inhaled corticosteroid therapy reduces cytokine levels in sputum from very preterm infants with chronic lung disease
Author(s) -
Honda Rie,
Ichiyama Takashi,
Sunagawa Shinpei,
Maeba Shinji,
Hasegawa Keiko,
Furukawa Susumu
Publication year - 2009
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2008.01071.x
Subject(s) - medicine , sputum , corticosteroid , cytokine , gastroenterology , respiratory disease , lung , anesthesia , pathology , tuberculosis
Aim: To evaluate the effects of inhaled corticosteroid therapy and high‐frequency oscillatory ventilation (oscillation) on preterm infants with chronic lung disease (CLD). Methods: Ten infants with CLD who received inhaled corticosteroid therapy were enrolled. Week 1 was defined as the first week of therapy. The concentrations of interleukin (IL)‐8, tumour necrosis factor‐α (TNF‐α), IL‐1β, IL‐6, IL‐10 and IL‐12p70 in serial sputum specimens from the infants were determined using a cytometric bead array. Results: The sputum concentrations of IL‐8 obtained from the infants during week 3–4 were significantly lower than those obtained before therapy and during week 1–2. The sputum concentrations of TNF‐α, IL‐6 and IL‐10 during week 3–4 were significantly lower than the concetrations during week 1–2. The ratio of IL‐8 levels during week 1–2 to those before therapy in infants who received oscillation (n = 4) was significantly lower than in those who received intermittent mandatory ventilation (n = 6). Conclusion: Inhaled corticosteroids may be associated with a decrease in pro‐inflammatory cytokine levels in sputum from infants with CLD from 2 weeks after the start of therapy. Our further investigations suggest that therapy with oscillation modulated airway inflammation earlier than therapy with intermittent mandatory ventilation.