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Correlation of 8‐isoprostane, interleukin‐6 and cardiac functions with clinical score in childhood obstructive sleep apnoea
Author(s) -
Biltagi Mohammed A,
Maguid Mohammed A,
Ghafar Mohammed A,
Farid Eman
Publication year - 2008
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2008.00927.x
Subject(s) - medicine , correlation , sleep (system call) , interleukin , isoprostane , cardiology , cytokine , oxidative stress , geometry , mathematics , computer science , operating system , lipid peroxidation
Objective: Adeno‐tonsillar hypertrophy is the commonest cause of childhood obstructive sleep apnoea (OSA). Our aim of the study is to correlate the severity of OSA with levels of 8‐isoprostane and interleukin‐6 (IL‐6) and with cardiac diastolic dysfunctions. Methods: Forty children with adenoidal hypertrophy and 20 control children were recruited. The OSA clinical score was evaluated and IL‐6 and 8‐isoprostane were measured in exhaled breath condensate. The cardiac functions were evaluated by conventional and tissue Doppler echocardiography (TDE). Results: Higher concentrations of isoprostane‐8 and IL‐6 were found in group with clinical score >40 (58.595 ± 2.86 pg/mL and 38 ± 1.77 pg/mL, respectively) than in control group (34.9 ± 1.5 pg/mL and 7.02 ± 0.3 pg/mL, respectively) {p < 0.0001*}. There was positive correlation between level of isoprostane‐8 and IL‐6 and value of clinical score {p < 0.0001*} and also with the degree of the cardiac dysfunction in those children. Conclusion: The severity of OSA as indicated by clinical score was positively correlated with degree of elevation of 8‐Isoprostane and IL‐6 in breath condensate of children with OSA and also with degree of cardiac dysfunction. Echocardiography and tissue Doppler modality are advised to examine these children.