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Adiponectin and peroxisome proliferator‐activated receptor γ expression in subcutaneous and omental adipose tissue in children
Author(s) -
Li Xiaonan,
Lindquist Susanne,
Angsten Gertrud,
Yi Jun,
Olsson Tommy,
Hernell Olle
Publication year - 2008
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2008.00715.x
Subject(s) - adiponectin , adipose tissue , endocrinology , medicine , peroxisome proliferator activated receptor , receptor , overweight , obesity , endocrine system , insulin resistance , hormone
Aim: To compare the expression levels of the adiponectin and peroxisome proliferator ‐activated receptor γ (PPARγ) genes in subcutaneous adipose tissue (SC) and omental adipose tissue (OM) in children with relation to age and anthropometric variables. Methods: Paired biopsies (SC and OM) were obtained from 53 children (age 0.2–14 years, BMI 12.5–25.8 kg/m 2 ). Adiponectin and PPARγ mRNA levels in adipose tissue were measured by real‐time PCR. Results: In overweight, but not in normal weight children, the median adiponectin mRNA level was significantly lower in OM [0.51 (0.1–2.17)] compared to SC [1.29 (0.16–5.08)], (p = 0.03). Adiponectin mRNA levels were strongly associated with PPARγ mRNA levels in both SC (r = 0.73, p < 0.001) and OM (r = 0.78, p < 0.001). Conclusions: The lower adiponectin expression in OM relative to SC in overweight children indicates that metabolic‐endocrine alterations begin already in childhood. The close association between adiponectin and PPARγ expression supports the hypothesis this transcription factor is involved in adiponectin gene regulation.