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Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum
Author(s) -
Chadie A,
Radi S,
Trestard L,
Charollais A,
Eurin D,
Verspyck E,
Marret S
Publication year - 2008
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2008.00688.x
Subject(s) - medicine , corpus callosum , agenesis of the corpus callosum , corpus callosum agenesis , magnetic resonance imaging , neurodevelopmental disorder , pediatrics , neuroimaging , prenatal diagnosis , agenesis , pregnancy , fetus , radiology , surgery , pathology , autism , psychiatry , genetics , biology
Aim: To evaluate long‐term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC). Methods: We retrospectively reviewed data for 20 children born between January 1991 and November 2003 in the Haute‐Normandie region of France with a prenatal diagnosis of isolated ACC. We collected data on pre‐and postnatal neuroimaging findings, clinical features at birth and neurodevelopmental outcomes. Results: Follow‐up ranged from 3 to 16 years. ACC was complete in 11 patients (55%), partial in 2 (10%), hypoplastic in 3 (15%) and associated with an interhemispheric cyst in 4 (20%). Neurodevelopmental outcome was normal in 11 (55%) patients, including 8 with complete ACC; moderate disability was present in 5 (25%) patients and severe disability in 4 (20%) patients. In 3 of the 4 patients with severe disability, postnatal cerebral magnetic resonance imaging (MRI) showed additional major cerebral abnormalities. Conclusion: Neurodevelopmental outcome was good in most of our patients with isolated ACC, with 80% of patients having normal outcomes or moderate disabilities. A prenatal diagnosis of isolated ACC may not warrant termination of pregnancy. A carefully interpreted prenatal cerebral MRI is crucial to detect associated cerebral abnormalities; a longer follow‐up is necessary to look for moderate disabilities.