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Allergic proctitis and abdominal distention mimicking Hirschsprung's disease in infants
Author(s) -
Lee Jee Hyun,
Choe Yon Ho,
Lee SukKoo,
Seo Jeong Meen,
Kim Ji Hye,
Suh YeonLim
Publication year - 2007
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2007.00536.x
Subject(s) - medicine , barium enema , incidence (geometry) , constipation , gastroenterology , rectum , hirschsprung's disease , biopsy , enema , proctitis , disease , surgery , colonoscopy , ulcerative colitis , colorectal cancer , physics , cancer , optics
Aim: To determine the incidence and clinical aspects of allergic proctitis (AP) in infants with symptoms that mimic Hirschsprung's disease (HD). Methods: One hundred and five patients less than 6 months of age, who underwent barium enema, anorectal manometry and rectal suction biopsy due to suspicion of HD, were enrolled. Comparison of the patient characteristics associated with each disease was based on the results of the triple testing. The sensitivity and specificity of the three tests, for the diagnosis of HD, were evaluated. Results: The mean age of enrolled patients was 2.1 ± 0.9 months. Based on the three tests, 39 patients (37.1%) were diagnosed with HD, seven patients (6.7%) with AP, and 53 (50.5%) had normal results. Of the 54 patients with transitional zone and a reversed rectosigmoid index on the barium enema, four (7.4%) were patients with AP. The mean age of the AP patients (3.1 ± 1.5 months old) was older than the HD children (1.4 ± 0.9 months old). The sensitivity of the three tests for HD was 97.4%, 87.2% and 92.3% and the specificity was: 74.2%, 78.8% and 100%, respectively. Conclusions: In the infants with severe abdominal distention, the incidence of AP mimicking HD was relatively high. Therefore, consideration of AP should be part of the differential diagnosis in infants with severe abdominal distention or findings that mimic HD. For differentiation of these disorders, a rectal suction biopsy is very useful.