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Outcome of childhood ulcerative colitis at 2 years
Author(s) -
Howarth LJ,
Wiskin AE,
Griffiths DM,
Afzal NA,
Beattie RM
Publication year - 2007
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2007.00515.x
Subject(s) - medicine , azathioprine , ulcerative colitis , colectomy , cohort , incidence (geometry) , immunosuppression , disease , pediatrics , inflammatory bowel disease , cohort study , surgery , physics , optics
Aim: Ulcerative Colitis (UC) has an incidence of 1.4 per 100 000 in childhood. There is a paucity of data regarding outcome particularly with the increased use of early immunosuppression. This study reviews outcome at 2 years in a cohort with UC referred to a single centre. Method: Patients were recruited on the basis of a diagnosis made between 2000 and 2003 as a consecutive cohort. All had UC according to standard clinicopathological criteria. Children with indeterminate colitis were excluded. Follow‐up data was collected at 2 years by case notes review. Results: Thirty‐two children are reported. The median age at diagnosis was 11 years (range 2–16). All were treated with corticosteroids and 5‐ASA derivatives at diagnosis. The majority of patients (94%, 30/32) received more than one course of steroids. By 2 years azathioprine use was high with 75% (24/32) of patients on treatment for steroid‐dependent disease. There were 6 extra‐intestinal manifestations and 8 disease related complications occurring in 12 patients (38%). The colectomy rate was 9% (3/32) for unresponsive disease. Conclusion: There is a high need for Azathioprine in childhood UC. Colectomy rate at 2 years was around 10%. Extra‐intestinal manifestations and disease related complications are common.