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Oestrogen receptors and linear bone growth
Author(s) -
Chagin Andrei S.,
Sävendahl Lars
Publication year - 2007
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2007.00415.x
Subject(s) - receptor , oestrogen receptor , medicine , endocrinology , selective estrogen receptor modulator , bone growth , estrogen receptor , cancer , breast cancer
In this review we summarize available data regarding linear growth in oestrogen receptor alpha (ERα)‐ and oestrogen receptor beta (ERβ)‐deficient mice. We discuss these findings in relation to known oestrogenic effects in humans and the possibility of applying this knowledge for the therapeutic modulation of longitudinal bone growth employing selective oestrogen receptor modulators (SERMs). We conclude that SERMs potentially could offer new possibilities to modulate bone growth by specifically targeting different oestrogen receptors within the growth plate.