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Nonfatal congenital alveolar dysplasia due to abnormalities of NO synthase isoforms
Author(s) -
Hegde S,
Pomplun S,
Hannam S,
Greenough A
Publication year - 2007
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2007.00394.x
Subject(s) - medicine , bronchopulmonary dysplasia , nitric oxide synthase , dysplasia , muscle hypertrophy , pulmonary hypertension , stenosis , lung , pathology , gene isoform , cardiology , nitric oxide , biochemistry , pregnancy , chemistry , genetics , gene , biology , gestational age
Congenital alveolar dysplasia (CAD) is a rare disorder thought to represent alveolar growth arrest at the canalicular stage of development. An infant with CAD diagnosed on lung biopsy is reported, her respiratory problems resolved spontaneously and she was doing well at follow‐up. The infant additionally suffered from systemic hypertension and hypertrophic pyloric stenosis. In conclusion, we speculate that the association of CAD with systemic hypertension and hypertrophic pyloric stenosis might be explained by abnormalities of isoforms of nitric oxide synthase (NOS) resulting in congenital deformities involving smooth muscles.