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Liver disease as risk factor for cystic fibrosis‐related diabetes development
Author(s) -
Minicucci L,
Lorini R,
Giannattasio A,
Colombo C,
Iapichino L,
Reali MF,
Padoan R,
Calevo MG,
Casciaro R,
De Alessandri A,
Haupt R
Publication year - 2007
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2007.00250.x
Subject(s) - medicine , cystic fibrosis , diabetes mellitus , gastroenterology , cystic fibrosis related diabetes , pancreatic disease , risk factor , disease , liver disease , cystic fibrosis transmembrane conductance regulator , family history , pulmonary function testing , fibrosis , type 2 diabetes , pancreas , endocrinology , impaired glucose tolerance
Aim: To evaluate clinical and genetic factors, besides pancreatic insufficiency, associated with increased risk of cystic fibrosis‐related diabetes. Methods: Case‐control (1:1) study on 138 cystic fibrosis patients. Data were collected on gender, age at diagnosis, reason for cystic fibrosis diagnosis, family history of type 1 or 2 diabetes mellitus, pre‐existing severe liver disease, and class of cystic fibrosis transmembrane regulation mutation. Moreover, information was obtained on lung involvement and degree of exocrine pancreatic insufficiency evaluated 1 year before the diagnosis of cystic fibrosis‐related diabetes in patients and age‐matched controls. Results: Compared to controls, patients with cystic fibrosis‐related diabetes had a higher probability of having already been diagnosed with liver disease (16.7% versus 1.7%, OR = 11.6, 95% CI 1.43–93.0). Moreover, in the year before diabetes onset, cases had slightly worse pulmonary function compared to controls (FEV 1 = 58.4 ± 27% predicted versus 67.4 ± 21% predicted; p = 0.05). No significant effects related to the other factors considered were found. Conclusion: Severe liver disease was found to significantly increase the risk of developing cystic fibrosis‐related diabetes. Patients with liver disease should be scheduled for earlier diabetes screening in order to identify and possibly treat glucose intolerance.