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Bone mass, biochemical markers and growth in children with chronic kidney disease: a 1‐year prospective study
Author(s) -
SwolinEide Diana,
Magnusson Per,
Hansson Sverker
Publication year - 2007
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2007.00236.x
Subject(s) - medicine , n terminal telopeptide , endocrinology , osteocalcin , bone remodeling , parathyroid hormone , osteoprotegerin , kidney disease , bone mineral , leptin , vitamin d and neurology , alkaline phosphatase , osteoporosis , obesity , calcium , biology , biochemistry , receptor , activator (genetics) , enzyme
Aim: This study was designed to investigate bone mineral density (BMD), growth parameters and biochemical markers in children with chronic kidney disease (CKD). Methods: Sixteen patients, 4–18 years, with CKD were prospectively followed for 1 year. Auxological data, body composition, BMD by dual‐energy X‐ray absorptiometry, bone age, bone turnover markers, vitamin D, parathyroid hormone (PTH), leptin, osteoprotegerin, insulin‐like growth factor‐I (IGF‐I) and IGF binding protein‐3 were measured. A questionnaire regarding bone health and diet was also performed. Results: Delayed bone age was observed (n = 11) and the BMD Z‐scores for total body were below zero in seven patients. However, total body BMD (TBBMD) increased in 12 patients. Most patients had increased osteocalcin and carboxy‐terminal telopeptide of type I collagen, but normal alkaline phosphatase, type I procollagen intact amino‐terminal propeptide and tartrate‐resistant acid phosphatase 5b. Ten patients had increased PTH. Most children had normal levels of leptin, osteoprotegerin, IGF‐I and IGFBP‐3. Leptin, at baseline, correlated with differences in TBBMD over 1 year. Conclusions: Only seven (44%) had negative Z‐scores and TBBMD increased over 1 year. Bone markers at baseline did not predict the longitudinal changes in BMD.