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Magnetic resonance imaging changes in Fabry disease
Author(s) -
Ginsberg Lionel,
Manara Renzo,
Valentine Alan R.,
Kendall Brian,
Burlina Alessandro P.
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2006.tb02391.x
Subject(s) - medicine , fabry disease , magnetic resonance imaging , abnormality , white matter , ectasia , radiology , vascular disease , infarction , disease , grey matter , fabry's disease , pathology , cardiology , surgery , myocardial infarction , psychiatry
Recognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non‐specific white and grey matter lesions, vascular anomalies, in particular dolicho‐ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age. Conclusion: MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.