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ApoB‐100 and ApoB/ApoA‐1 ratio in children and adolescents from families with very early myocardial infarction
Author(s) -
Dirisamer Albert,
Stadler Alfred,
Bucek Robert. A.,
Widhalm Kurt
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2006.tb02345.x
Subject(s) - apolipoprotein b , medicine , myocardial infarction , family history , endocrinology , grandparent , cholesterol , psychology , developmental psychology
Dirisamer A, Stadler A, Bucek RA, Widhalm K. ApoB‐100 and ApoB/ApoA‐1 ratio in children and adolescents from families with very early myocardial infarction. Acta Paediatrica 00. Stockholm. ISSN 0803–525. Aim: The relationship between apolipoprotein B, LDL/ApoB, ApoB/ApoA‐1, lipids and a family history of very early myocardial infarction (parent and/or grandparent <45 years) was studied in 46 children compared with 64 controls. Methods: 19 children came out of families with a myocardial infarction (MI) of the father and 27 children with MI of a grandparent. Results: In the whole risk group LDL‐C, ApoB and ApoB/ApoA‐1 ratio showed the most significant relationship, whereas in children from families with MI of the father ApoB level showed the strongest association with family history of MI. No relationship could be found for ApoA1, HDL‐C and LDL/ApoB. Conclusion: Our results show that levels of ApoB, LDL‐C and ApoB/ApoA‐1 might be better predictors in children from families of very early MI as compared with ApoA‐1, HDL‐C and LDL/ApoB.