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Attention‐deficit/hyperactivity disorder: A plausible mouse model?
Author(s) -
Gra Sylvie,
Changeux JeanPierre
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2006.tb02310.x
Subject(s) - attention deficit hyperactivity disorder , nicotine , nicotinic agonist , medicine , attention deficit , psychiatry , receptor
Attention‐deficit/hyperactivity disorder (ADHD) is a multifactorial and heterogeneous disorder, highly prevalent in children and characterized by three main components: inattention, lack of inhibitory control and hyperactivity. Epidemiological evidence reveals that ADHD is associated with nicotine exposure, mostly, with prenatal cigarette smoking. Mice deleted for the β2‐subunit gene of the neuronal nicotinic receptor are proposed as a simple and reliable animal model for ADHD. Conclusion: Nicotinic agonists targeting the α4β2 nicotinic receptors alleviate ADHD symptoms and may possibly contribute to an efficient therapy of ADHD children.