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Clinical predictors of self‐limited urinalysis abnormality in childhood Henoch‐Schönlein purpura nephritis
Author(s) -
Hung ShuoHsun,
Yang YaoHsu,
Lee ChienChang,
Wang LiChieh,
Lin YuTsan,
Chiang BorLuen
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2006.tb02231.x
Subject(s) - urinalysis , medicine , abnormality , multivariate analysis , nephritis , logistic regression , cohort , gastroenterology , univariate analysis , urine , psychiatry
Background and aim: The majority of patients (85–95%) with Henoch‐Schönlein purpura nephritis (HSPN) suffer from a prolonged course of urinalysis abnormality. We sought to identify favourable prognostic factors predicting a self‐limited urinalysis abnormality within 1 y. Methods: Fifty‐eight HSPN patients admitted to the University Hospital between 1990 and 2003 were retrospectively analysed. Detailed information on clinical and laboratory manifestations on admission and sequential follow‐up clinics were recorded. The χ 2 or Fisher's exact test were used for univariate analysis, and multiple logistic regression was used for multivariate analysis. Results: The study cohort included 31 boys and 27 girls, with a mean age of onset of 8.0±4.3 y and a median follow‐up duration of 5.9 y (range 1 to 25). Of 58 patients, 39 (67.3%) had a self‐limited urinalysis abnormality within 1 y. On multivariate analysis, onset age less than 9 ( p =0.038), low‐grade proteinuria ( p =0.044) and interval between purpura onset and renal manifestations less than 2 wk ( p =0.005) predicted self‐resolved urinalysis abnormality within 1 y. With two or more predictive factors, the sensitivity for short‐term course was 84.6%, the specificity was 73.7%, and the positive predictive value was 84.8%. Conclusion: A small number of variables were important for detecting a favourable short‐term course of urinalysis abnormality.