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Elevation of serum creatine kinase in response to medical treatment of Graves’ disease in children
Author(s) -
Mizuno Haruo,
Sugiyama Yukari,
Nishi Yoshikazu,
Ueda Noriko,
Ohro Yoichiro,
Togari Hajime
Publication year - 2006
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2006.tb02214.x
Subject(s) - medicine , euthyroid , creatine kinase , graves' disease , hormone , disease , thyroid , endocrinology , antithyroid drugs , antithyroid agent , gastroenterology
We describe two cases of increases in serum creatine kinase (CK) concentrations in children undergoing treatment of Graves’ disease with antithyroid medications. Presenting complaints consisted of myalgias and muscle cramping in both patients, and increases in serum CK levels were noted 1 mo after initiation of antithyroid drugs. Both patients were euthyroid at the time of CK elevation. While the mechanisms for this process are not clear, it is likely that the acute decrease of thyroid hormones in tissues following a state of chronic hyperthyroidism may result in relative hypothyroid states and subsequent alterations in CK concentrations. Conclusion: Although this side effect has been reported in adults, it is a novel finding in children. Clinicians should be aware of the rare potential for elevations in serum CK when initiating treatment for Graves’ disease in children.