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Hypertrophic osteoarthropathy in two children with cholestatic hepatic disease
Author(s) -
Katsicas M,
Ciocca M,
Rosanova M,
Russo Ricardo AG
Publication year - 2005
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb02062.x
Subject(s) - medicine , hypertrophic osteoarthropathy , liver transplantation , polyarthritis , spinal osteoarthropathy , disease , cholestatic jaundice , transplantation , liver disease , pathology , gastroenterology , cholestasis , arthritis
Aim: To describe two children with hypertrophic osteoarthropathy associated with cholestatic hepatic disease. Both patients suffered from chronic progressive cholestatic liver disease and developed digital clubbing, polyarthritis and periosteal reaction. In one of them, clinical and radiological features normalized after liver transplant. Conclusion: Hepatic hypertrophic osteoarthropathy is a rare disabling condition that responds poorly to conservative management, while liver transplantation appears to be the only effective therapeutic intervention.