Premium
Severe hypothyroidism due to atrophic thyroiditis from second year of life influenced developmental outcome
Author(s) -
Joergensen JV,
Oerbeck B,
Jebsen P,
Heyerdahl S,
Kase BF
Publication year - 2005
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb02044.x
Subject(s) - medicine , pediatrics , thyroiditis , outcome (game theory) , thyroid , mathematics , mathematical economics
From the second year of life a girl showed an insidious development of clinical hypothyroidism due to a non‐goitrous lymphocytic thyroiditis without traceable circulating levels of thyroid antibodies measured by routine immunoassays. The diagnostic delay of this rare variant of atrophic thyroiditis caused persistent neuropsychological deficits. Conclusion: Her difficulties with speed of processing and working memory in particular could suggest a frontal deficit, possibly in the dorsolateral prefrontal circuit. This contrasts with findings in congenital hypothyroidism, suggesting a relatively preserved frontal function, and could illustrate different neuropsychological deficits of hypothyroidism at different ages in early childhood.