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Interferon γ and tumour necrosis factor α in relation to anaemia and prognosis in childhood cancer
Author(s) -
Ek Torben,
Mellander Lotta,
Abrahamsson Jonas
Publication year - 2005
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb01914.x
Subject(s) - medicine , childhood cancer , interferon , necrosis , cancer , tumor necrosis factor alpha , oncology , immunology , cancer research
This study examined whether the initial plasma levels of tumour necrosis factor α (TNFα) and interferon γ (IFNγ) in 131 children with newly diagnosed cancer were associated with haematopoietic suppression, and whether plasma levels of TNFα or haemoglobin at diagnosis affects long‐term prognosis in childhood acute lymphoblastic leukaemia (ALL). Conclusions: IFNγ, and possibly also TNFα, were related to anaemia in children with solid tumours. Neither TNFα levels nor Hb levels were associated with increased risk of ALL relapse.