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Hyperglycaemia and insulinopenia in a neonate with cystic fibrosis
Author(s) -
Siahanidou Tania,
Mandyla Helen,
Doudounakis Stavros,
Anagnostakis Dimitris
Publication year - 2005
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb01864.x
Subject(s) - medicine , cystic fibrosis , cystic fibrosis related diabetes , diabetes mellitus , impaired glucose tolerance , incidence (geometry) , complication , pediatrics , el niño , endocrinology , type 2 diabetes , physics , optics
Abnormal glucose tolerance is a frequent late complication of cystic fibrosis (CF), but the prevalence of CF‐related diabetes mellitus (CFRD) in children less than 10 y old is less than 2%. The youngest child with CFRD reported to date was 6 mo of age. Insulinopenia is the primary cause of abnormal glucose tolerance/CFRD, but it is unknown whether it may begin in the neonatal period. We describe a case of a neonate with CF who presented with hyperglycaemia in the diabetic range and marked insulinopenia. Insulinopenia and impaired glucose tolerance were permanent findings at 6 and 15 mo of age. Conclusion: This case suggests that abnormal glucose tolerance/diabetes may occur much earlier in the course of CF, even during neonatal age. Careful follow‐up and further studies in CF infants could reveal that the real incidence of glucose intolerance and diabetes in this age group has been underestimated.