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Interleukin‐13 is involved in the survival of children with sepsis
Author(s) -
Blancoquirós Alfredo,
Casadoflores Juan,
Garrote Adrados Jose A,
Nieto Moro Monserrat,
Asensio Antón Julia,
Arranz Sanz Eduardo
Publication year - 2005
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb01861.x
Subject(s) - medicine , sepsis , pathogenesis , cytokine , atopy , immunology , septic shock , refractory (planetary science) , interleukin , shock (circulatory) , gastroenterology , allergy , physics , astrobiology
Forty‐eight children with sepsis were studied. Interleukin‐13 (IL‐13) levels were lower in patients who died at admission ( p =0.014) and at 6 h ( p =0.037), and in patients with refractory shock at 0 ( p =0.03) and particularly at 6 h ( p =0.0009). IL‐13 levels did not correlate with other cytokines (IL‐1b, IL‐10, IL‐12, TNFr), CRP or neutrophil count. Low IL‐13 levels in the early hours of sepsis are associated with poor prognosis. Conclusion: IL‐13, a Th‐2 cytokine fundamental in the pathogenesis of atopy, might also have a protective role against severe infections in children.