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Systemic lupus erythematosus (SLE) presenting with nephrotic syndrome and membranous glomerulopathy in a 10‐year‐old girl
Author(s) -
Machado Vânia,
Pontes Teresa,
Brito Iva,
Afonso Caldas
Publication year - 2005
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2005.tb01829.x
Subject(s) - medicine , nephrotic syndrome , serositis , prednisolone , lupus nephritis , renal biopsy , anti nuclear antibody , cyclophosphamide , dermatology , glomerulonephritis , proteinuria , systemic lupus erythematosus , gastroenterology , immunology , arthritis , biopsy , disease , kidney , antibody , autoantibody , chemotherapy
The authors report the case of a 10‐y‐old girl with clinical diagnosis of systemic lupus erythematosus (SLE), made at the age of 6 y, based upon arthritis, serositis, haematological disorder and positive antinuclear antibody. The first manifestation of disease—Raynaud's phenomenon—appeared at the age of 4 y. Seven months after the diagnosis, she developed nephrotic proteinuria with haematuria. Percutaneous renal biopsy showed membranous glomerulonephritis, the least common form of lupus nephritis. Conclusion: Intravenous cyclophosphamide therapy associated with oral prednisolone proved effective in inducing complete remission of nephrotic syndrome.