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Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children
Author(s) -
Singh M,
Mathew JL,
Chandra S,
Katariya S,
Kumar L
Publication year - 2004
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2004.tb02626.x
Subject(s) - medicine , streptokinase , empyema , surgery , decortication , pleural empyema , anesthesia , myocardial infarction
Aim : To compare intrapleural streptokinase and placebo in paediatric empyema. Methods : Children with empyema greater than stage 5 received intrapleural streptokinase ( n = 19) or normal saline ( n = 21) along with intercostal drainage. Clinical and serial sonographic outcomes were compared. Results : Although there was no difference in clinical and sonographic outcome, none of the children with stage 7 empyema (multi‐loculated empyema) who received streptokinase developed pleural thickening 30 d later. Conclusion : There is no short‐term clinical benefit of intrapleural streptokinase in paediatric empyema; this therapy may be reserved for those with stage 7 empyema to prevent pleural thickening in the long term.