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Early nasal continuous positive airway pressure in a cohort of the smallest infants in Denmark: neurodevelopmental outcome at five years of age
Author(s) -
Hansen BM,
Hoff B,
Greisen G,
Mortensen EL
Publication year - 2004
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2004.tb00704.x
Subject(s) - medicine , cohort , pediatrics , airway , cohort study , continuous positive airway pressure , anesthesia , obstructive sleep apnea
Aim : To evaluate neurodevelopmental outcome at age 5 y of age in a cohort of preterm children treated mainly with nasal continuous positive airway pressure (CPAP) in the neonatal period. Methods : A national prospective observational study was conducted in Denmark which included all 269 surviving children with a birthweight below 1000 g or a gestational age below 28 wk born in Denmark in between 1994 and 1995. A total of 164 children (61%) had been treated with nasal CPAP only in the neonatal period. A reference group ( n = 76) of term children was studied in parallel. Results : Of the 269 surviving children, 252 (94%) were examined. Twenty‐four children (10%) had cerebral palsy, and three children were blind. No case of hearing impairment was detected. Nineteen percent of the index children had an IQ score >‐2 SD and 42% had an IQ score >‐1 SD of the mean score of the reference group. Conclusions : The intellectual development of children in this cohort treated with early nasal CPAP did not suggest a higher proportion of adverse effects on the brain compared to the published follow‐up studies of preterm children treated with mechanical ventilation. In our population‐based cohort, however, the survival rate for infants below 25 wk of gestation was relatively low and this may indicate a limit for the use of early nasal CPAP.