Premium
Azithromycin in the treatment of cholera in children
Author(s) -
Bhattacharya MK,
Dutta D,
Ramamurthy T,
Sarkar D,
Singharoy A,
Bhattacharya SK
Publication year - 2003
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2003.tb00598.x
Subject(s) - azithromycin , medicine , erythromycin , cholera , vibrio cholerae , diarrhea , randomized controlled trial , antibiotics , clinical trial , clinical efficacy , gastroenterology , microbiology and biotechnology , virology , genetics , biology , bacteria
Aim : To evaluate the efficacy of azithromycin in the treatment of cholera in children. Methods : A double‐blind, randomized, controlled clinical trial on 80 children with acute watery diarrhoea and moderate to severe dehydration compared the efficacy of azithromycin and erythromycin in treating cholera. Data were analysed for 56 patients who were stool culture positive for Vibrio cholerae. In conjunction with rehydration therapy, 29 patients received azithromycin and 27 patients received erythromycin. Patients in the two treatment groups had comparable clinical and blood biochemical characteristics on admission. Results : Patients who received azithromycin had significantly less stool output, shorter duration of diarrhoea and lower fluid intake compared with patients who received erythromycin. Conclusion : Azithromycin appears to be superior to erythromycin for treating cholera in children.