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Analysis of the mitochondrial genome in sudden infant death syndrome
Author(s) -
Divne AM,
RåstenAlmqvist P,
Rajs J,
Gyllensten U,
Allen Marie
Publication year - 2003
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2003.tb00562.x
Subject(s) - medicine , sudden infant death syndrome , genome , mitochondrial dna , pediatrics , genetics , gene , biology
Aim : To investigate the mitochondrial genome and its association with sudden infant death syndrome (SIDS). Methods : Twenty SIDS infants were screened for previously reported mitochondrial DNA mutations using direct sequencing. The whole mitochondrial genome was also sequenced for six of the infants. Results : Three substitutions, A11467G, A12308G and G12372A, comprising a haplogroup were present in four infants diagnosed as pure SIDS. This haplogroup was also common in a control group. Conclusions : No specific mutation or polymorphism was found in association with SIDS.