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Benefits and risks of calcium resonium therapy in hyperkalaemic preterm infants
Author(s) -
Grammatikopoulos T,
Greenough A,
Pallidis C,
Davenport M
Publication year - 2003
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2003.tb00481.x
Subject(s) - medicine , randomized controlled trial , perforation , calcium , calcium supplementation , pediatrics , surgery , anesthesia , materials science , punching , metallurgy
The occurrence of an intestinal perforation in a prematurely born infant following rectal administration of a calcium resonium resin prompted a literature review to determine whether use of resins in neonates was evidence based. This revealed that the results of anecdotal series suggested that resins were useful, but the only randomized trial including prematurely born infants demonstrated that resins were less efficacious than glucose and insulin infusions. Important side effects were reported including colonic necrosis and impaction with perforation. Conclusion : The risks and benefits of exchange resins in prematurely born infants should be assessed in an appropriately sized randomized trial.