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Calcium and phosphorus retention in extremely preterm infants supplemented individually
Author(s) -
Trotter A,
Pohlandt F
Publication year - 2002
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2002.tb03302.x
Subject(s) - medicine , calcium , phosphorus , gestational age , zoology , excretion , endocrinology , weight gain , gestation , urine , pregnancy , body weight , chemistry , biology , organic chemistry , genetics
The aim of this study was to investigate the correlation between the retention of calcium (Ca) and phosphorus (P) and weight gain and intake of Ca and P when using the concept of individualized Ca and P supplementation in extremely low birthweight infants. Three‐day Ca and P balances were performed in 20 infants with a mean gestational age of 26.6 wk (between 24.1 and 28.7 wk) and a birthweight of 744 g (450–990), when the infant was able to tolerate at least 100 ml/kg/d of milk. The daily supplementation with Ca and P was individually adjusted to achieve a simultaneous excretion of ± 1.2 mmol/L Ca and ± 0.4 mmol/L P in the urine. In 16 of the 20 infants, the urinary concentrations of both Ca and P exceeded the lower limits. The retention of Ca (mean 3.8 mmol/kg/d, minimum 0.9; maximum 8.1; 57% of intake, 34–80) and P (2.4,1.1–4.2; 76%, 52–96) was significantly correlated with both the daily weight gain (16 g, 3–28; Ca r 2 = 0.22, p = 0.02; P r 2 = 0.21, p = 0.03) and the intake of Ca (6.5 mmol/kg/d, 2.4–10.2; r 2 =0.67, p > 0.001) and P (3.1,1.9–5.3; r 2 = 0.85, p > 0.0001). The molar ratio of the Ca and P intake was 2.2 (1.3–4.0). Conclusion : It was found that Ca and P retention was a function of growth and intake.