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Mechanisms underlying thrombocytopenia in the neonatal intensive care unit
Author(s) -
Sola MC,
Rimsza LM
Publication year - 2002
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2002.tb02907.x
Subject(s) - medicine , neonatal intensive care unit , megakaryocyte , intensive care medicine , intensive care unit , intensive care , mechanism (biology) , pediatrics , platelet , platelet transfusion , immunology , philosophy , stem cell , epistemology , haematopoiesis , biology , genetics
Thrombocytopenia is one of the most common hematological problems among neonates in the neonatal intensive care unit (NICU), but in the majority of cases the kinetic mechanism responsible is unclear. This review focuses on both traditional and innovative methods used to evaluate the mechanisms responsible for thrombocytopenia in neonates, and analyzes the data generated from those methods. Conclusion : Results of studies using new methods for evaluating thrombocytopenia, coupled with recent descriptions of marrow megakaryocyte mass, suggest that decreased platelet production complicates most cases of thrombocytopenia among neonates in the NICU.