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Early‐onset Group B streptococcal sepsis in a preterm infant with Kostmann syndrome
Author(s) -
Fujiu T,
Maruyama K,
Koizumi T
Publication year - 2002
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2002.tb02840.x
Subject(s) - medicine , sepsis , histopathology , neutropenia , group b , neonatal sepsis , granulocyte , absolute neutrophil count , immunology , pathology , toxicity
A preterm infant died of group B streptococcal sepsis 7 h after birth. The infant's complete blood count showed total agranulocytosis. Histopathology of the major organs showed significant bacterial invasion without infiltration of polymorphonuclear leucocytes. Examination of the bone marrow revealed normal cellularity of the granulocyte precursors with arrested maturation. These findings are consistent with Kostmann syndrome. Conclusion : It is suggested that in patients with deteriorating early‐onset infection, underlying congenital abnormalities in host defence, such as Kostmann syndrome, should be considered.