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Supplementary oxygen and risk of childhood lymphatic leukaemia
Author(s) -
Naumburg E,
Bellocco R,
Cnattingius S,
Jonzon A,
Ekbom A
Publication year - 2002
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2002.tb02829.x
Subject(s) - medicine , odds ratio , asphyxia , resuscitation , confidence interval , population , pediatrics , apgar score , obstetrics , pregnancy , birth weight , anesthesia , environmental health , biology , genetics
Aim : Childhood leukaemia has been linked to several factors, such as asphyxia and birthweight, which in turn are related to newborn resuscitation. Based on the findings from a previous study a population‐based case‐control study was performed to investigate the association between childhood leukaemia and exposure to supplementary oxygen and other birth‐related factors. Methods : Children born in Sweden and diagnosed with lymphatic leukaemia between 1973 and 1989 (578 cases) were individually matched by gender and date of birth to a randomly selected control. Children with Down's syndrome were excluded. Exposure data were blindly gathered from antenatal, obstetric and other standardized medical records. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated by conditional logistic regression. Results : Resuscitation with 100% oxygen with a facemask and bag immediately postpartum was significantly associated with an increased risk of childhood lymphatic leukaemia (OR = 2.57, 95% CI 1.21–6.82). The oxygen‐related risk further increased if the manual ventilation lasted for 3 min or more (OR = 3.54, 95% CI 1.16–10.80). Low Apgar scores at 1 and 5 min were associated with a non‐significantly increased risk of lymphatic leukaemia. There were no associations between lymphatic leukaemia and supplementary oxygen later in the neonatal period or other birth‐related factors. Conclusion : Resuscitation with 100% oxygen immediately postpartum is associated with childhood lymphatic leukaemia, but further studies are warranted to confirm the findings.