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Seizures in paediatric Chiari type I malformation: the role of single‐photon emission computed tomography
Author(s) -
Iannetti P,
Spalice A,
Felice Ciccoli C,
Bruni O,
Festa A,
Maini CL
Publication year - 2002
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2002.tb01721.x
Subject(s) - medicine , ictal , magnetic resonance imaging , single photon emission computed tomography , electroencephalography , epilepsy , central nervous system disease , radiology , surgery , psychiatry
Chiari type I malformation is one of the posterior fossa maldevelopments with which different clinical manifestations have been associated. Seizures have only recently been associated with Chiari type I malformation. This study reports on 4 children with epilepsy (2M, 2F; age range 8–15 y) diagnosed with Chiari type I malformation by brain magnetic resonance imaging (MRI), in whom no cortical structural involvement was observed. In these patients an interictal ethylcysteinate‐dimer‐single‐photon emission computed tomographic (ECD‐SPECT) study was performed to define more precisely the relationship between Chiari type I malformation and seizures. In these patients the hypoperfusion area correlated with electroencephalographic (EEG) focal abnormalities. These hypoperfusion s may represent the functional aspect of a cerebral microdysgenesis; seizures and EEG epileptic anomalies may also be linked to the complex network connection between cortices and cerebellar hemispheres. A cerebellar hypoperfusion was also detected in two of the four examined patients, indicating a functional or structural involvement. Conclusion : Interictal SPECT scans are helpful for the clarification of seizures in patients with Chiari type I malformation.