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Liver involvement in alpha 1 ‐antitrypsin‐deficient phenotypes PiSZ and PiMZ
Author(s) -
Pittschieler K
Publication year - 2002
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2002.tb01702.x
Subject(s) - medicine , phenotype , elevated liver enzymes , limiting , liver enzyme , gastroenterology , pediatrics , physiology , pregnancy , genetics , biology , gene , mechanical engineering , engineering
The long‐term outcome of 3 PiSZ and 57 PiMZ children affected by alpha 1 ‐antitrypsin deficiency‐associated liver involvement during infancy was assessed. At 5 and 10 y of age all PiSZ and PiMZ children exhibited normal levels of liver enzymes. All families, except one, were deterred from smoking following counselling. Conclusion : Transient liver involvement observed during early infancy is likely to be a benign self‐limiting process.