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Whole blood ionized magnesium in neonatal acidosis and preterm infants: a prospective consecutive study
Author(s) -
Olofsson K,
Matthiesen G,
Rudnicki M
Publication year - 2001
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2001.tb01603.x
Subject(s) - medicine , umbilical cord , acidosis , gestational age , img , anesthesia , cord blood , pregnancy , immunology , biology , computer science , genetics , operating system
The mineral magnesium is a crucial enzymatic cofactor in the cellular bioenergetic process and alternations in magnesium metabolism may be associated with neurological impairment in newborn infants. Therefore, ionized magnesium (IMg) was measured in 14 newborn infants with acidosis [umbilical arterial cord pH 7.00 ± 0.06, Apgar score 8.3 ± 1.6 after 5 min, gestational age (GA) 276 ± 16d] and 15 premature infants (umbilical arterial cord pH 7.31 ± 0.07, GA 236 ± 12 d). Nineteen healthy mature infants served as controls. Arterial umbilical cord samples were taken immediately after delivery and capillary blood samples were taken 2, 6, 12 and 24 h after delivery by heel stick. IMg was measured by NOVA 8. The results showed an increased umbilical cord blood IMg in infants with acidosis compared with both premature and normal infants (0.58 ± 0.08 mmol 1 −1 vs 0.51 ± 0.03 mmol 1 −1 and 0.49 ± 0.03 mmol 1 −1 ; p < 0.0001). In infants with acidosis IMg declined significantly 2 h after delivery to 0.49 ± 0.05 mmol 1 −1 ( p < 0.0001) and did not show any further significant changes during the first day of life. In premature infants and controls IMg levels were constant during the observation period. Conclusion : These findings suggest that elevated IMg is associated with neonatal acidosis.