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Paroxysmal tonic upgaze of childhood: effect of age‐of‐onset on prognosis
Author(s) -
Verrotti A,
Trotta D,
Blasetti A,
Lobefalo L,
Gallenga P,
Chiarelli F
Publication year - 2001
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2001.tb01587.x
Subject(s) - medicine , pediatrics , electroencephalography , psychomotor learning , age of onset , disease , tonic (physiology) , eye disease , surgery , psychiatry , cognition
Paroxysmal tonic upgaze (PTU) is a syndrome of childhood manifesting as sudden ocular movements with sustained upward deviation of the eyes. We describe the outcome of 6 patients, after a follow‐up of 10 years, with onset of the disease in childhood. The aims of this study were to clarify some clinical features of this syndrome and to evaluate the long‐term prognosis of these children. In all the patients, tonic upgaze episodes disappeared with time to remission, varying from 1 to 4 y, without any therapy and without any change in psychomotor development, EEG and neuroimaging. Only one child had pathologic interictal EEG with temporo‐occipital spikes, which persisted after the offset of the disease. Conclusion : From a long‐term follow‐up, we can confirm the good prognosis of PTU and suggest it is possible to define a distinct syndrome of childhood without any neurological abnormalities and with spontaneous resolution.