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Malassezia pachydermatis fungaemia in a neonatal intensive care unit
Author(s) -
Chryssanthou E,
Broberger U,
Petrini B
Publication year - 2001
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2001.tb00312.x
Subject(s) - medicine , neonatal intensive care unit , fungemia , itraconazole , malassezia , fluconazole , colonization , amphotericin b , cluster (spacecraft) , microbiology and biotechnology , flucytosine , intensive care unit , epidemiology , typing , mycosis , pediatrics , immunology , antifungal , dermatology , biology , computer science , programming language
Malassezia pachydermatis , a non‐obligatory lipophilic yeast, has occasionally been implicated in nosocomial fungaemias. This study investigated a cluster of eight cases of M. pachydermatis infection and colonization in a neonatal intensive care unit over a 6 mo period. All patients were preterm with very low birthweight and suffered from various underlying diseases. Prolonged use of indwelling catheters and parenteral lipid formulations were important predisposing factors for their infection. All M. pachydermatis strains were susceptible to amphotericin B, fluconazole and itraconazole but resistant against flucytosine. Conclusion: Molecular typing by random amplification of polymorphic DNA showed distinct banding profiles for each blood isolate. Since no epidemiological association among the strains could be shown, the reason for this cluster of nosocomial fungaemias remains unclear.