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Reed‐Sternberg cells in atypical primary EBV infection
Author(s) -
Bitsori M,
Stiakaki E,
Tzardi M,
Kalmanti M
Publication year - 2001
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2001.tb00290.x
Subject(s) - hepatosplenomegaly , medicine , mononucleosis , reed–sternberg cell , atypical lymphocyte , epstein–barr virus , epstein–barr virus infection , serology , pathology , lymphoma , biopsy , virus , antibody , immunology , hodgkin lymphoma , disease
The presence of Epstein‐Barr virus (EBV) in the Hodgkin's/Reed‐Sternberg (HRS) cells of a significant proportion of cases of Hodgkin's lymphoma (HL) is a matter of consideration when a case of presumptive HL has to be differentiated from infectious mononucleosis (IM). A 15‐y‐old boy was admitted with a presumptive diagnosis of extranodal HL, based on the biopsy of a painless ulcer on the right mandibular alveolar crest. Histologic examination of the lesion was consistent with mixed cellularity HL. The patient additionally presented with hepatosplenomegaly and regional lymphadenopathy. Serology for EBV was indicative of acute infection. Histological examination of regional lymphoid tissue was consistent with immunologic activation due to primary EBV infection. The patient was left untreated, under close observation. All clinical findings resolved within 3 mo and EBV viral capsid antigen (VCA) IgM antibodies converted to negative after 6 mo. A 3‐y follow‐up period was uneventful.