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Plasma thrombomodulin levels in children with atopic dermatitis
Author(s) -
Yoshijima S,
Kojima T,
Sasai M,
Hattori K,
Taniuchi S,
Kobayashi Y
Publication year - 2001
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2001.tb00272.x
Subject(s) - thrombomodulin , medicine , atopic dermatitis , eosinophil , plasma levels , inflammation , allergic inflammation , immunology , gastroenterology , asthma , platelet , thrombin
Plasma thrombomodulin (TM) levels were measured in 68 patients with atopic dermatitis (AD) and 35 controls. Plasma TM levels in patients with AD were significantly higher than those of controls ( p < 0.01). A significant correlation was observed between plasma TM levels and skin scores of AD or peripheral eosinophil counts ( p < 0.01). There was also a positive correlation between plasma TM and vascular cell adhesion molecule‐1 levels ( p < 0.05). Conclusion: These results suggest that plasma TM levels may reflect a severity of AD and/or endothelial cell activation induced by an allergic inflammation.