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Inflammatory pathways between placenta and foetus
Author(s) -
Hallman Mikko
Publication year - 2001
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2001.tb00245.x
Subject(s) - medicine , fetus , ards , respiratory distress , glucocorticoid , immunology , placenta , amniotic fluid , lung , pregnancy , proinflammatory cytokine , inflammation , surgery , genetics , biology
Recent evidence indicates that intra‐amniotic endotoxin (LPS) and interleukin‐1 alpha (IL‐1α) accelerate foetal lung maturity and protect from respiratory distress syndrome (RDS) more effectively than does antenatal glucocorticoid. Inflammatory cytokines promote development of chronic lung disease in the premature, acute RDS (ARDS) in children and adults. Systemic exposure to LPS or cytokines can result in generalized multiorgan damage. The abnormal host defence in the foetus and the premature newborn need to be considered in therapeutic interventions.