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Acyclovir‐resistant varicella infection with atypical lesions in a non‐HIV leukemic infant
Author(s) -
Crassard N,
Souillet AL,
Morfin F,
Thouvenot D,
Claudy A,
Bertrand Y
Publication year - 2000
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2000.tb02785.x
Subject(s) - medicine , human immunodeficiency virus (hiv) , virology , chickenpox , pediatrics , dermatology , virus
An HIV‐negative infant presented with VZV primary infection during the maintenance therapy for mega‐karyoblastic leukaemia. The lesions were initially vesicular and necrotic but became verrucous and hyperkerato tic. A clinical resistance to acyclovir was suspected and confirmed by histologic and virologic studies. The patient was successfully treated by foscarnet. Conclusion: resistance of VZV to acyclovir may occur after a short treatment in a non‐AIDS patient. ± Acute leukaemia, acyclovir, foscarnet, Varicella zoster virus