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Does maternal or paternal heredity affect carotid atherosclerosis in children with familial hypercholesterolaemia?
Author(s) -
Tonstad S,
Joakimsen O,
Leren TP,
Ose L
Publication year - 2000
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.2000.tb02782.x
Subject(s) - medicine , heredity , intima media thickness , pregnancy , ultrasonography , aorta , endocrinology , obstetrics , pediatrics , carotid arteries , surgery , genetics , biology
Maternal hypercholesterolaemia has recently been shown to increase the number of fatty streaks in the foetal aorta, as well as subsequent progression of fatty streaks to more advanced lesions. We compared carotid intima‐media thickness by B‐mode ultrasonography in children who inherited familial hypercholesterolaemia from their mothers or fathers, hypothesizing that children whose mothers were hypercholesterolaemic during pregnancy had increased atherogenesis compared with children whose mothers did not have familial hypercholesterolaemia. We found that carotid intima‐media thickness and prevalence of plaque did not differ between children with familial hypercholesterolaemia who inherited FH maternally or paternally.