Premium
The transmission of prions to humans
Author(s) -
Will RG
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb14400.x
Subject(s) - bovine spongiform encephalopathy , medicine , transmission (telecommunications) , disease , incidence (geometry) , population , disease transmission , encephalopathy , identification (biology) , virology , environmental health , pathology , prion protein , psychiatry , biology , telecommunications , physics , optics , botany , computer science
The identification of new‐variant Creutzfeldt‐Jakob disease (nvCJD) in 1996 led to the proposalhd that this new disease was caused by the transmission of bovine spongiform encephalopathy (BSE)ve epidemiologyof Creutzfeldt‐jakob disease in six to the human population. The ramifications of such a proposal have been extensive and profound,8; 43: 763–7 both politically and on the general public in the UK and other countries. Patients with nvCJD: 960–70 exhibit a consistent set of clinicopathological features, and cases of nvCJD continue to be reportedob disease (spongiform enceer almost exclusively in the UK, the country with by far the highest incidence of BSE. Laboratory studies, including transmission experiments in mice, provide strong support for the hypothesis that nvCJD is caused by BSE.