Premium
Truncated growth hormone receptor isoforms
Author(s) -
Ross RJM
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb14378.x
Subject(s) - medicine , gene isoform , growth hormone , receptor , hormone receptor , endocrinology , hormone , genetics , gene , biology , cancer , breast cancer
Ross RJM. Truncated growth hormone receptor isoforms. Acta Pædiatr 1999; Suppl 428: 164–6. Stockholm. ISSN 0803–5326 Truncated forms of the growth hormone receptor (GHR) that lack the majority of the cytoplasmic domain have been identified in a number of human tissues. In vitro , these truncated receptors act as dominant‐negative inhibitors of the growth hormone (GH) signal and also generate large amounts of growth hormone binding protein (GHBP). Mutations that lead to high levels of expression of the truncated GHR are associated with short stature and GH insensitivity. Thus, truncated GHRs may be important as a physiological regulator of GH signalling in addition to providing a mechanism for the production of GHBR □ Cirrhosis, growth hormone, growth hormone insensitivity, growth hormone receptor, growth hormone resistance, truncated growth hormone receptor