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Comparison of the incidences of neuroblastoma for screened and unscreened cohorts
Author(s) -
Bessho F
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb01130.x
Subject(s) - medicine , neuroblastoma , pediatrics , demography , genetics , sociology , biology , cell culture
The incidences of neuroblastoma in screened cohorts and unscreened cohorts were compared to evaluate the usefulness of neuroblastoma mass screening. Data for screened and unscreened populations were collected from annual reports from the Neuroblastoma Committee and the number of cases of neuroblastoma with information on the screening history was provided by the Japan Children's Cancer Registry, whose registration rate has been estimated to be 0.71. In the age category of 6–11 months, the ratios of incidences per 10 6 person‐years for unscreened to screened cohorts were 6.58 [95% confidence intervals (CI) 4.51‐9.60] during the early period, 1985–1989, and 11.15 (95% CI 7.65‐16.25) during the later period, 1990–1994. However, they were 0.67 (95% CI 0.31‐1.44) and 0.81 (95% CI 0.33‐2.03) for the age categories of 1–4 y and 2–4 y during the early period and 1.32 (95% CI 0.63‐2.76) and 1.17 (95% CI 0.48‐2.89) for the age categories of 1–4 y and 2–4 y, respectively. The incidences of neuroblastoma per 10 person‐years were not different among screened and unscreened cohorts. Neuroblastoma mass screening has not contributed to any decrease in the incidence of neuroblastoma in children over 1 y of age.