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Killed oral Shigella vaccine made from Shigella flexneri 2a protects against challenge in the rabbit model of shigellosis
Author(s) -
Chakrabarti MK,
Bhattacharya J,
Bhattacharya MK,
Nair GB,
Bhattacharya SK,
Mahalanabis D
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb01075.x
Subject(s) - shigellosis , shigella flexneri , medicine , shigella , microbiology and biotechnology , dysentery , virology , escherichia coli , biology , salmonella , bacteria , pathology , biochemistry , genetics , gene
The protective efficacy of an orally administered heat‐killed virulent strain of Shigella flexneri 2a (5 weekly oral doses) was evaluated in 25 rabbits (14 immunized and 11 non‐immunized controls) against challenge with the same strain of Shigella using the rabbit model of shigellosis. All 11 non‐immunized rabbits developed bloody diarrhoea following challenge and 6 (54%) died. None of the 14 immunized rabbits developed diarrhoea (all had pellet stools) but 3 (21%) died from causes not associated with diarrhoea. Protection from diarrhoea and dysentery following oral immunization with a killed Shigella species was 100% and highly significant. Death following challenge was 2.5‐fold higher in the non‐immunized group ( p = 0.115) but was not significant. These promising results suggest that further studies should be undertaken to develop a killed oral vaccine against shigellosis.