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Transmission of primary nocturnal enuresis and attention deficit hyperactivity disorder
Author(s) -
Bailey JN,
Ornitz EM,
Gehricke JG,
Gabikian P,
Russell AT,
Smalley SL
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb01052.x
Subject(s) - proband , attention deficit hyperactivity disorder , medicine , enuresis , linkage (software) , genetic disorder , genetic linkage , inheritance (genetic algorithm) , nocturnal , transmission (telecommunications) , twin study , psychiatry , genetics , disease , biology , mutation , heritability , gene , electrical engineering , engineering
Primary nocturnal enuresis (PNE) is a prevalent disorder among children with a complex mode of inheritance. Family, twin, and linkage studies have provided evidence that genetic factors underlie the familiarity of PNE. Linkage investigations support the hypothesis that PNE is heterogeneous, and the genetic heterogeneity may be reflected in co‐morbid clinical conditions such as attention deficit hyperactivity disorder (ADHD). This study used a family study method and examined the transmission of PNE in relatives of PNE and control probands with and without ADHD, to determine if these disorders co‐occur due to common genetic susceptibilities or other, i.e. non‐genetic, reasons. This study concluded that the pattern of inheritance found is consistent with the independent transmission of PNE and ADHD.