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Effect of age on cerebrospinal fluid levels of metabolites of biopterin and biogenic amines
Author(s) -
Komori H,
Matsuishi T,
Yamada S,
Ueda N,
Yamashita Y,
Kato H
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb01048.x
Subject(s) - medicine , biopterin , cerebrospinal fluid , tetrahydrobiopterin , nitric oxide synthase , nitric oxide
We identified an age effect on biopterin and biogenic amine metabolites in the cerebrospinal fluid from 56 neurologically normal patients, aged 1 mo to 80 y. The levels of total and reduced forms of biopterin, homovanillic acid, and 5‐hydroxyindoleacetic acid were found to peak during the first year of life. The levels of these metabolites then gradually decreased, plateauing at the age of 20 y. We found significant correlations between biopterin, homovanillic acid, and 5‐hydroxyindoleacetic acid.