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Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic‐ischaemic encephalopathy
Author(s) -
Roldán A,
FiguerasAloy J,
Deulofeu R,
Jiménez R
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb01002.x
Subject(s) - medicine , asphyxia , cerebrospinal fluid , glycine , perinatal asphyxia , encephalopathy , asphyxia neonatorum , neurotransmitter , hypoxia (environmental) , anesthesia , hypoxic ischemic encephalopathy , amino acid , central nervous system , biochemistry , oxygen , biology , chemistry , organic chemistry
The aim of this study was to evaluate the concentrations of neurotransmitter amino acids in the cerebrospinal fluid (CSF) of asphyctic newborns, and to establish whether these concentrations are related to the degree of hypoxic‐ischaemic encephalopathy (HIE). Levels of glutamate, aspartate, glycine and taurine in CSF were measured in 48 full‐term newborns during the first 2 d of life. Thirty‐nine of these newborns had birth asphyxia and were divided into three groups: 11 without HIE, 19 with mild HIE and 9 with moderate HIE. None suffered from severe HIE. They were compared with a control group of 9 non‐hypoxic newborns. Determinations of the amino acids in CSF were made by chromatography and expressed as μmol/1 (mean ± SD). CSF glycine value was related to erythrocyte count, and CSF taurine value was related to its plasmatic level. Levels of CSF glycine were related to the severity of HIE ( p = 0.020): control (12.08 ± 4.04 μmol/1), without HIE (12.49 ± 4.04 μmol/1), mild HIE (12.14 ± 3.83 μmol/1), and moderate HIE (19.1 ± 10.08 μmol/1; p <0.05 versus mild HIE), even after removing the influence of red cells in CSF.