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Intracardiac fungal masses in high‐risk neonates: clinical observations
Author(s) -
Daftary AS,
Patole SK,
Whitehall JS
Publication year - 1999
Publication title -
acta pædiatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/j.1651-2227.1999.tb00198.x
Subject(s) - medicine , intracardiac injection , systemic candidiasis , amphotericin b , incidence (geometry) , antibiotics , surgery , pediatrics , antifungal , dermatology , physics , microbiology and biotechnology , corpus albicans , optics , biology
Four cases of intracardiac fungal masses occurred over 2 y amongst 7 cases of systemic candidiasis in a neonatal referral unit. The gestations and birthweights were 25, 23, 24 and 30 wk and 805, 605, 640 and 1395 g, respectively. The pedunculated, solitary right atrial masses were detected 2—17 d after diagnosing candidemia in 3 cases, whereas it was the presenting feature in the 4th. All had indwelling right atrial catheters and received multiple courses of broad‐spectrum antibiotics. The masses were removed successfully in two cases fit for surgery. None survived despite antifungal therapy, including liposomal amphotericin B at 6 mg/kg/d. Early introduction of enteral feeds, minimization of prolonged exposure to broad‐spectrum antibiotics and judicious use of central catheters may reduce the incidence of systemic candidiasis in high‐risk neonates. Surveillance echocardiography and timely surgical intervention may reduce the mortality and/or morbidity related to intracardiac fungal masses. □ Candidiasis, intracardiac mass, liposomal amphotericin B, neonate